Anti-aquaporin 4 antibody in Japanese multiple sclerosis: the presence of optic spinal multiple sclerosis without long spinal cord lesions and anti-aquaporin 4 antibody
نویسندگان
چکیده
منابع مشابه
Low sensitivity of anti-aquaporin-4 antibody in multiple sclerosis, longitudinally extensive spinal cord lesions and neuromyelitis optica in Australians
Background and Objective: Multiple Sclerosis (MS) is the most common neurological disease of young adults in Western countries. The spectrum of demyelinating disease in Western countries is characterised by predominance of conventional MS and small proportion of neuromyelitis optica (NMO). NMO is similar to optic-spinal MS reported in Asia in many aspects. It has been argued that relapsing NMO ...
متن کاملHeterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in multiple sclerosis in Japanese.
Opticospinal multiple sclerosis (OSMS) in Asians has similar features to the relapsing-remitting form of neuromyelitis optica (NMO) seen in Westerners. OSMS is suggested to be NMO based on the frequent detection of specific IgG targeting aquaporin-4 (AQP4), designated NMO-IgG. The present study sought to clarify the significance of anti-AQP4 autoimmunity in the whole spectrum of MS. Sera from 1...
متن کاملThe role of anti-aquaporin-4 antibody in Asian patients with multiple sclerosis: Confusions and controversies
Neuromyelitis optica (NMO) was first described as a severe monophasic syndrome of acute bilateral optic neuritis and transverse myelitis. Whether it is a form of multiple sclerosis (MS) or a separate disease entity has been continually debated since the beginning of last century. The redefinition of NMO as a relapsing disease, the wider use of magnetic resonance imaging showing longer spinal co...
متن کاملIgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord. It is considered a severe variant of multiple sclerosis (MS), and frequently is misdiagnosed as MS, but prognosis and optimal treatments differ. A serum immunoglobulin G autoantibody (NMO-IgG) serves as a specific marker for NMO. Here we show that NMO-IgG binds selectively ...
متن کاملOptic Nerve and Spinal Cord Are the Major Lesions in Each Relapse of Japanese Multiple Sclerosis
For the purpose of predicting multiple sclerosis (MS) and neuromyelitis optica (NMO) relapses in Japanese population, we evaluated the localization and age of each demyelinating attack. We retrospectively analyzed the 78 medical records of Japanese MS and NMO patients. Then we identified 49 cases of relapsing-remitting-type patients and defined each of 116 demyelinating attacks. NMO had an olde...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 2007
ISSN: 0022-3050
DOI: 10.1136/jnnp.2006.114165